Google's pushing Unicode 5.1, the latest version of the ginormous meta-lingual character set, less than a month after it was released. Though Unicode surpassed ASCII and other encoding systems a few months ago, googleblog now has a pretty graph.
I once wrote a script that would translate ISO to Mac Roman in whatever way needed, so this one server which ran on some ancient, decrepit Mac running something like system 8 wouldn't munge our text workflow at the place I worked at. I am particularly sensitive to the empty square boxes of doom. I have had dreams about giant grids, with hexadecimally-named columns and rows, where every cell contains only the proprietary Apple character. Or some random thingie with an umlaut or whatever the hell Apple decided to put where the apostrophe should be.
Moving to Unicode 5.1 [Googleblog]