Pixel art book jackets
I don't think much of the idea of wrapping all my books in custom jackets, and I'm deeply distrustful of anyone who would meticulously arrange their bookshelves as a reading lover, but that all said: these pixel art dust jackets do make a neat little effect, at least to see once or twice.
Books Help to Create Icons [Icoeye via Geeksugar]

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That's great, if you happen to own 200 copies of the same book.
Otherwise, how do you find that many books of uniform size, and how do you find the book you want to read?
I do see this as a useful marketing tool, if an author (or the editor of a series) were to have each of his book covers designed so as to fit into an overall pattern when arranged on the shelf like this. Obsessive-compulsives would simply HAVE to purchase all the books in a series.
I can see doing this with something that's already really nerdy: my D&D books. All the same size, more or less the same thickness. And man I have plenty of them.
I've seen similar things done with books or videotapes that were part of a series; it can be a good quick visual cue that you've got them back in the intended order. Of course those were generally using something a bit more high-res than this pixelization.
As far as distructing organized bookshelves: Depends on what you mean by "organized". I do keep mine divided by general category, and the fiction categories are alphabetized. New books get piled in more-or-less the right places until I cam find time to sort them in (generally waiting until there's no more room for the pile).
I'm also trying to maintain a library catalog, mostly because I got tired of "That looks interesting... oh, I already had a copy; now what am I going to do with the duplicate."
(You can never have too many good books. You can, however, have a shortage of bookcases.)
Doesn't have to be pixel art, can be regular photos. You make the book jackets yourself, and the books can be different sizes. First you arrange the books in the order you want, then measure them and input into your computer, type a couple of words to describe the genre. Off the computer goes to flickr, and returns a couple of likely photos for you to choose from. It then prints the book jackets. All you do is fold it around the books. Oh, and somebody has got to write the program first. :-)
Tokyopop, are you paying attention?